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In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)

Elevated ethylmalonicacid and methylsuccinic acid have been associated with developmental delay, hypotonia, and vascular instability associated with lactic acidemia (Nowaczyk et al, 1998)