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Semaglutide is a selective GLP-1 receptor agonist, engaging only the GLP-1R

This effect is linked to how semaglutide regulates appetite and digestion

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

In nonenzymatic autoxidations, free ferrous iron interacts with hydrogen peroxide to form ferric iron and hydroxyl radicals, which commences the process of lipid peroxidation by detaching hydrogen from the bis-allylic position of PUFAs (Reis and Spickett, 2012)

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