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Furthermore, p62 is also an autophagy substrate, and it is used as an autophagy marker [280]
doi: 10.1016/j.ijscr.2023.108166 215
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice
At the time, there was skepticism about weight loss drugs on the market and widespread belief that obesity is a behavioral problem, not a medical condition
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Over-dosing frequency without mechanistic justification adds cost, increases injection site trauma in animal models, and complicates circadian confounding variables without improving endpoint sensitivity
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