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In addition, our single-cell RNA sequencing data for islet cell differentiation indicated that FGFR1 was highly expressed in pancreatic endocrine cells, including alpha cells, beta cells and pancreatic endocrine progenitors, further supporting the concept that FGF21 participates in beta cell regeneration

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This pattern matters because it suggests that the primary risk window for tolerability issues is the first 8 to 12 weeks