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While it is not "mandatory" in the sense that the supplements won't work without it, Vitamin C is highly recommended as a co-factor

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Pentadeca Arginate Complex works at a cellular level to enhance the bodys natural mechanisms for repair and maintenance, so the effects may be gradual

"Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis." Proc Natl Acad Sci

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This phenomenon is known as metabolic endotoxemia