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Cagrilintide Starting Dose and Titration Unlike tirzepatide's gradual multi-step escalation, cagrilintide trials have typically employed a simpler titration approach: Typical Cagrilintide Escalation: Weeks 1-4: 0.6 mg weekly Weeks 5-8: 1.2 mg weekly Week 9 onward: 2.4 mg weekly (maintenance) This three-step approach allows for tolerance development while reaching the therapeutic dose more quickly than tirzepatide's six-step protocol

Inspection of the BMI % phenotype revealed a heavy tailed distribution, so we further quality controlled the BMI % phenotype to remove outlier participants with BMI changes above 20% or below 45% (Extended Data Fig

However, call your doctor if the soreness worsens or lasts more than 2-3 days