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Given the conflicting evidence, it is plausible that the impact of GDF15 on EE is context dependent, requiring pharmacologically relevant plasma concentrations and prolonged exposure to trigger sustained metabolic changes

Yamazaki N, Matsuo T, Kurata M, Suzuki M, Fujiwaki T, Yamaguchi S, Terada H, Shinohara Y: Substitutions of three amino acids in human heart/muscle type carnitine palmitoyltransferase I caused by single nucleotide polymorphisms

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