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Microglial dysfunction further impairs synaptic pruning, maintaining immature excitatory synapses and disrupting excitatoryinhibitory balance, a hallmark of ASD-related cognitive and behavioral deficits (Toscano et al
Limitations and Advances While our study offers a multidimensional and functionally validated characterization of early neuronal metabolic remodeling, several limitations related both to the model and the study design must be acknowledged
LaRowe SD, Myrick H, Hedden S, et al
Drug and chemical toxicology , 44 (3), 302309
Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)
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