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After incubation, cells were exposed to the mix, in a final concentration of 30 nM siRNA, according to the manufacturers protocol
Discontinuation rates due to adverse events in major trials were relatively low, generally under 10%, but higher than placebo
Outcomes: Primary outcomes were mean weight loss (kg) and proportion of participants achieving 5% or 10% weight loss
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A significant portion of the existing knowledge about FOXO4-DRI's safety and side effects emanates from anecdotal accounts, particularly from the biohacker community
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