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Current Pharmaceutical Design, 20(7), 11261135
Nakamura et al
Endocrinology Diabetes & Metabolism, 7(1)
Treatment of cells with hydroxychloroquine or bafilomycin-A1, which increase the lysosomal pH and prevent iron(III) unloading from its endocytic carriers, led to reduced pools of chelatable cellular iron(III) and reactive lysosomal iron(II), as measured using specific fluorescent probes 27,28
At 6 months, the median weight change was -2.6 kilograms, and at 12 months, it was -4.2 kilograms
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