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These molecules, in turn, are considered responsible for the hallmark characteristics that mark the progression of periodontal disease, including the destruction of periodontal (Nussbaum and Shapira, 2011) tissue and inflammation, which may contribute to metabolic dysregulation ( Figure 1 ) (Manosudprasit et al., 2017)

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Flexible dosinggive intramuscularly or intravenously

Standard refrigeration temperatures maintain quality adequately

Tissue irritation resolves within 24 to 48 hours in the majority of reported cases when proper site rotation and sterile technique are used

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