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Even so, because of the known side effects, the medication is always started at a low dose and periodically escalated following a fixed schedule, he says

Like other TZDs, activates PPARs and is a selective ligand of PPAR with no PPAR-binding action

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Regarding atrial fibrillation (AF) and tachycardia, the inverse associations observed in the full dataset were not replicated in HCP-restricted analyses