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Class observed outcomes in study models: decreased pressure in the lower oesophageal and the pyloric [PMID: 28516373] Laboratory literature summary: Class observed outcomes in study models: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine
We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig
Thiyagarajan, D
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