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Change history 15 February 2025 A Correction to this paper has been published: Abbreviations AAV: Adeno-associated virus ACEA: Arachidonoyl 2-chloroethylamide AEA: Anandamide 2-AG: 2-Arachidonoylglycerol BiP: Binding-immunoglobulin protein CBD: Cannabidiol CB1R: Cannabinoid type 1 receptor CB2R: Cannabinoid type 2 receptor CNR1KD: Cannabinoid receptor 1 knockdown CXCL10: C-X-C motif chemokine ligand 10 DAGL: Diacylglycerol lipase ECS: Endocannabinoid system ER: Endoplasmic reticulum GSIS: Glucose-stimulated insulin secretion IEQ: Islets equivalent MAGL: Monoacylglycerol lipase PBMC: Peripheral blood mononuclear cell RNS: Reactive nitrogen species ROS: Reactive oxygen species References International Diabetes Federation IDF Diabetes Atlas