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Body composition (DEXA or similar) only useful with a long enough window to detect change

Studies show that within a year of stopping treatment, patients typically regain about two-thirds of their prior weight loss

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They can also be found in blood vessels, in the peripheral nervous system, in the joints, the lungs, the heart, the alpha cells of the pancreas, and in the kidneys, giving them many different functions in the body: activating a protein here, lowering a different protein there, playing a role in intricate paths of cause and effect, getting things done

For patients who need to use medication for a long time, especially those who have a fear of injections or have difficulty operating them, this can significantly improve patient compliance, ensure that patients use medication on time and in the right amount, and thus improve treatment effectiveness

However, electrophysiological studies revealed that GLP-1 or exendin-4 does not change the spontaneous firing activity as well as the synaptic transmission suggesting lack of functional GLP-1R in PPG neurons (Reiner et al., 2016)