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Colton Jones, MD, the lead researcher and a hematology and medical oncology fellow at the University of Texas at San Antonio, and colleagues analyzed the health records of nearly 8,800 people with breast cancer and obesity taking both hormonal therapy and GLP-1s

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Important safety considerations include the risk of hypoglycemia when tirzepatide is used in combination with insulin or sulfonylureas (requiring dose adjustments of these medications), potential thyroid C-cell tumor risk (contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and the possibility of acute pancreatitis

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