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Se is an essential trace element for the human body and specifically for the human brain (Ingold et al., 2018), but it also can be highly neurotoxic depending on intake and speciation (Rayman, 2012
Some shifts are the benefits you want
Under the stimulation of oxidative stress, keratinocytes are induced to produce CXC chemokine ligand (CXCL) 16, which further recruits CXCR6 + CD8 + T cells and the infiltration of such T cells in the skin is followed by the loss of melanocytes in vitiligo lesions (Li et al., 2017)