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Via several processes, including insulin and leptin resistance, perivascular adipose tissue dysfunction, reduced kidney function, activation of the renin-angiotensin-aldosterone system, and increased sympathetic nervous system activity, obesity can cause hypertension

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Still, subjects with a prior history of thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN-2) should be excluded from dulaglutide or semaglutide study [25]