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After propensity score matching against multiple antidiabetic drug classes (insulin, metformin, SGLT-2 inhibitors, DPP-4 inhibitors, sulfonylureas), results showed: No significant increase in thyroid cancer incidence Median follow-up of ~4.5 years Risk estimates comparable or lower than other glucose-lowering therapies Overall, current epidemiological evidence does not support a clinically meaningful increase in thyroid cancer risk in humans

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Individual Variation: Baseline pigmentation darkness, genetics, and sun damage history affect timeline

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Sriram, K., & Manzanares, W

Many patients describe feeling younger overallnot surprising given that the therapy restores growth hormone patterns closer to those of youth