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Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases [PMID: 8284946] Laboratory literature summary: Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases

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Preclinical studies have demonstrated no significant toxicity even at doses far exceeding therapeutic ranges

Expecting 10% weight loss means vastly different absolute numbers for a 200-pound man versus a 350-pound man