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In addition to adequate diet and exercise, they will assist in making greater use of calories and getting energy from fats
doi: 10.1016/S0140-6736(23)01127-3 105 KnopFKArodaVRdo ValeRDHolst-HansenTLaursenPNRosenstockJet al
doi: 10.1002/hep.23998 203 ArguelloGBalboaEArreseMZanlungoS
In the recently published BARI-OPTIMISE double-blind, placebo-controlled trial, 70 patients post-SG or RYGB who were tested and found to have insufficient GLP-1 response to meal stimulation were randomized to receive liraglutide (3 mg/day) or placebo, in addition to lifestyle interventions [49]
Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]
Peptides can influence the microbiome through several mechanisms, including antimicrobial activity, selective modulation of bacterial populations, and strengthening of epithelial defenses
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