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Presented for research literature review only Udovicic M et al

Vitamin B12 deficiency can be occurring while vitamin B12 levels are at levels not typically associated with deficiency due to the presence of deleterious MTHFR mutations

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Nutrients, 14 (9), 1727

It doesn't go well with the other skincare ingredients, including the Retin-A, hydroxy acids, vitamin C, etc