Another PSMA-based ADC investigated for the treatment of mCRPC, MEDI3726, also had similar issues with delivering its pyrrolobenzodiazepine (tesirine, SG3249) payload to the tumor without off-target effects due to heavy-light chain dissociation in the antibody 75
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van Rossum EF, Voorhoeve PG, te Velde SJ, Koper JW, Delemarre-van de Waal HA, Kemper HC et al
The TGF-beta1 suppression finding provides a plausible mechanism for follicle growth extension (Pyo et al., 2007)
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