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Striking the Balance of GLP-1 and Glucagon Agonism to Minimise Potential Risks Based on outcomes from safety and pharmacokinetic studies with GLP-1 analogues, the most common side effect observed with GLP-1 agonism is dose-dependent nausea and vomiting ( Even with careful engineering of receptor balance, potency and pharmacokinetics, problems may still crop up, as illustrated by SAR425899s unexpected development failure due to excessive gastrointestinal adverse events during its Phase 2 trials

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The notice from the BMS suggests those using both oral HRT and GLP-1s switch to a higher dose or stronger form of progestin to preserve the protection the hormone provides against endometrial cancer

Ultimately, the decision between simultaneous initiation and sequential add-on therapy should be individualized, considering patient-specific factors such as comorbidities, baseline kidney function, and treatment goals

(2024, May 16)

Personally I think it feels weird and messed around with my lip movement