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4.2.2.2 Metabolic significance of phenylacetylglutamine Phenylacetylglutamine (PAGln) is a gut microbiota-dependent metabolite that has attracted considerable attention in recent years, formed from dietary phenylalanine metabolized by gut microbiota to phenylacetic acid and subsequently conjugated with glutamine in the liver (126)
doi: 10.1002/jnr.22565 69 AlvarezEMartnezMDRonceroIChowenJAGarca-CuarteroBGispertJDet al
(Gastroenterology, 2008) showed KPV reduces NF-B activation and is taken up via PepT1 in mouse colitis models
Competing interests PG has received occasional fees, either personally or institutionally, for the activities of speaking, scientific advising, or clinical research from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Gilead, GlaxoSmithKline, Merck Sharp & Dohme, Novo Nordisk, Organon, Pfizer, and Sanofi
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