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1.1 Overview of cerebral ischemia-reperfusion injury 1.1.1 Definition and current status CIRI refers to the phenomenon where, after a period of cerebral ischemia, the restoration of blood flow leads to further exacerbation of ischemic damage

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Although current guidelines (ESH and ACC/AHA) recommend the measurement of arterial stiffness for personalized risk stratification of patients with hypertension, a better understanding of its pathophysiology is needed to define new targets for prevention and to bring us closer to healthy vascular aging