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Once a target is identified, the de-thicketing analysis begins: a systematic, claim-by-claim assessment of every patent in the innovators Orange Book listing and broader portfolio to identify those most vulnerable to P.IV challenge on invalidity (obviousness, anticipation, inadequate written description, enablement) or non-infringement grounds

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Abd El Aziz MS, Meier JJ, Nauck MA

This studys strength lies in its prospective design and objective gastric ultrasound assessment, reducing potential bias inherent in retrospective reviews [34]

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