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KLFs, particularly KLF2 and KLF4, are critical shear-responsive transcription factors that maintain the vascular barrier and endothelial quiescence by promoting anti-inflammatory and anti-thrombotic phenotypes and regulating metabolism [200, 201]

424 In AD, GLP-1(7-36) amide inhibits IL-1 transcription and prevents cognitive dysfunction, amyloid precursor protein synthesis, and cell death

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These drugs are meant to be taken long-term