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In Phase 3 TRIUMPH-4, retatrutide at 12 mg produced 28.7% body weight loss at 68 weeks vs 2.1% for placebo

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This is because it helps in the formation of collagen fiber as well as decreases the growth of inflammatory cells, as documented in a study published in the Journal of Burns

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The Phase 2 NEJM trial mapped this relationship across four dose tiers, and the Phase 3 TRIUMPH-4 data confirmed it at scale (Jastreboff et al., NEJM, 2023)

Unstable or contaminated formulations, or the wrong pH, can irritate regardless of how carefully you apply them