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The observed differences in free GSH, GSSG, and their respective ratio is likely due to spontaneous oxidation of free GSH in the heparinized plasma rather than a matrix effect of anticoagulant type used during sample collection

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This oxidative stress damages cellular membranes, proteins, and DNA

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The peptide worked whether given before or after ethanol exposure

GCGR activation stimulates hepatic glucose production between meals, increases lipolysis and fatty acid oxidation in the liver, elevates basal energy expenditure, and promotes thermogenesis