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The lactate transported from astrocytes into neurons plays a crucial role in activating signaling cascades via MCT2 and HCAR1 (GPR81) receptors, involving plasticity-associated genes [183, 184]

Larger randomized placebo-controlled trials including a variety of patient populations (ie, those with metabolic syndrome versus those without) are needed to confirm efficacy of GLP-1RAs according to patient type

Inhibition of L-carnitine biosynthesis and transport by methyl--butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

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Benefits of caloric restriction for cardiometabolic health, including type 2 diabetes mellitus risk

GLP-1 medications are the first medications that directly affect the hormones responsible for hunger, she says