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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
& Nubler-Jung, K
Sensitivity analyses included a mixed-effects model for repeated measures and exclusion of post-baseline data from non-adherent participants to confirm robustness
A key aspect of MQC is mitophagy mediated by mitochondria to remove inactivated or damaged mitochondria [18]
Serum biochemical parameters The influence of Spirulina supplementation on the blood biochemical indices of broilers exposed to ochratoxin A was illustrated in Table 6
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