Furthermore, smoking induces vascular vasoconstriction, sinusoidal endothelial dysfunction, and smooth muscle proliferation, leading to hypoxia, capillarization of sinusoids, and further activation of HSCs [18]
Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS
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Moreover, inflammation dysregulates neurotrophins such as BDNF and NGF, which are essential for neuronal growth and plasticity via TrkA/B/C and p75^NTR^ signaling pathways (Numakawa and Kajihara 2023