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"Obesity, like many other chronic diseases, is a progressive, relapsing disease, which may require long-term treatment," Jaisinghani says a framing now codified in the World Health Organization's first global GLP-1 guideline, issued in December 2025, which conditionally recommends these therapies as part of a comprehensive obesity treatment approach
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Patients with a history of digestive issues should engage in open discussions with their healthcare providers to determine the most appropriate treatment plan
This adjustment did not attenuate the observed correlations (cystine and CPT1A, r = 0.67, p = 0.002
