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1 Introduction Gastric cancer is the third most frequent cause of cancer-related death, and the fifth most diagnosed malignancy around the world ( Helicobacter pylori ( H
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Erythrocyte deformability and eryptosis during inflammation, and impaired blood rheology
Mechanisms: GSH precursor restores depleted hepatic stores antidote for acetaminophen poisoning Mucolytic: breaks disulfide bonds in mucus lowers viscosity (COPD, CF, bronchiectasis) Glutamate modulator: regulates extrasynaptic glutamate & cysteineglutamate exchange possible benefit in psychiatry Antiinflammatory: NFB, TNF, IL6 attenuates cytokine storm (sepsis, ARDS)
SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis
Oxidized glutathione (GSSG) is simply a sign that stress has been handled
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