Examples include Substance P and Endorphins
While it is primarily used for its glucose-lowering effects, recent research has suggested that semaglutide may also have some neurologic benefits
A person is not going to lose half of their body weight and sustain it, and the risks of doing that probably outweigh the benefits. However, percentages tend to take your whole health situation into account (e.g., hormonal life stage, health conditions, etc.) and research shows that losing certain percentages of weightnot a magic numbercan benefit your health
10.1016/j.cgh.2018.05.004 77 KongL.WangL.WangZ.XiaoX.YouY.WuH.et al (2020)
Mental health effects were not a primary endpoint in these studies, though adverse event reporting captured some psychiatric symptoms
By directly inhibiting this receptor, GLP-1 compounds reduced pain signaling at the most fundamental level