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severe or persistent upper abdominal pain should prompt urgent medical assessment [10] [11] Dehydration and acute kidney injury (AKI): gastrointestinal fluid losses can lead to dehydration, which may precipitate AKI, particularly in those with pre-existing renal impairment or those taking nephrotoxic medicines Delayed gastric emptying: this may affect the absorption of orally administered medicines, including contraceptive pills and thyroid replacement therapy [11] Injection site reactions: redness, bruising, or discomfort at the subcutaneous injection site Heart rate changes: increases in resting heart rate have been noted with GLP-1 class agents [14] [15] Hypoglycaemia: particularly if used alongside insulin or sulphonylureas Potential pancreatitis risk: a class concern with GLP-1 receptor agonists

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Visual Format: Side-effect and safety matrix Key Labels: Topical irritation, allergic reaction, formulation sensitivity, wound-care context, injectable route, limited safety data, peptide impurities, immunogenicity risk Suggested Layout: Create a three-column matrix: Topical products, Wound-care study context, and Injectable or compounded preparations. Under each column, list route-specific safety considerations using short, neutral labels