Invest 116 , 32403251 (2006)
a)(semaglutide)0.01-3.5 mg/ml(semaglutide)0.5-10 mg/ml(semaglutide)b)0.1%(w/w)c)d)e)60%f)In some embodiments, the pharmaceutical formulation comprises a) semaglutide, such as 0.01-3.5 mg/ml semaglutide or 0.5-10 mg/ml semaglutide, optionally b ) No more than 0.1% (w/w) phenol, c) Sodium chloride as an isotonic agent, d) Buffer solution, e) At least 60% water and f) Histidine
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Abbreviations EMT: Epithelial mesenchymal transition TME: Tumor microenvironment TIMER: Tumor Immune Estimation Resource HGSOC: High grade serous ovarian carcinoma EOC: Epithelial ovarian cancer MET: Mesenchymal epithelial transition PBS: Phosphate buffered saline BSA: Bovine serum albumin OCR: Oxygen consumption rate OXPHOS: Oxidative phosphorylation ECAR: Extracellular acidification rate 2-DG: 2 Deoxy glucose TCA: Tricarboxylic acid ECM: Extracellular matrix CTC: Circulating tumor cells G6PD: Glucose-6-phosphate dehydrogenase PPP: Pentose phosphate pathway ITGA2: Integrin alpha-2 ITGAV: Integrin alpha-V ITGA1: Integrin alpha-1 FLNA1: Filamin-A TGFBI: Transforming growth factor induced protein AKR1B1: Aldoreductase GFPT2: Glutaminefructose-6-phosphate aminotransferase HPRT1: Hypoxanthineguanine phosphoribosyltransferase SDPR: Serum deprivation-response protein CALB2: Calretinin ALCAM: CD166 antigen KTN1: Kinectin SEPT2: Septin-6 FSCN1: Fascin FLNC1: Filamin-C PCK2: Phosphoenopyruvate carboxykinase ACACA: Acetyl-CoA carboxylase 1
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