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Adverse effects included higher risks of nausea, vomiting and diarrhea, while risks of suicide, hypoglycemia, retinopathy, and pancreatitis were not increased

In a post hoc analysis from the PROactive trial, weight gain with pioglitazone, a TZD, which leads to weight gain with a redistribution from VAT to SCAT and improvements in insulin sensitivity 62,63 , was associated with improved CV outcomes (excluding heart failure) 64

In addition to possibly being more effective, drugs like retatrutide could also potentially benefit a broader population

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Contact your GP or healthcare professional (for example, your GP, pharmacist or diabetes specialist) if you experience: Palpitations that are persistent, severe, or accompanied by chest discomfort Dizziness or lightheadedness , particularly if associated with near-fainting episodes Chest pain or pressure , especially during physical activity Shortness of breath that is new or worsening, particularly at rest Unusual fatigue or reduced exercise tolerance A resting heart rate consistently above 100 beats per minute when measured at rest For urgent but non-emergency concerns, you can contact NHS 111 for advice

Importantly, the decision applies only to the obesity indicationtirzepatide remains available in its anti-diabetic medication (ADM) formulation (sold as Mounjaro) for patients with type 2 diabetes