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These compounds are often explored for different reasons

For CT, maxadilan, and CGRP, a disulfide linkage precludes helix propagation to the N-terminus, while for UCN1 and CRF the presence of proline residues near the N-terminus discourages local -helicity

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Glutamine has been considered an immunomodulatory amino acid in several disease states, yet the mechanisms underlying the therapeutic effects of glutamine supplementation in critical illness remain poorly understood

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