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JAMA Psychiatr 2020;77:180-9

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The upregulated Pt transporters [e.g., organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and copper transporters 1/2 (Ctr1/2)] in DGR increase the accumulation of Pt drugs in peripheral nerves as the first step to induce PIPN (Sprowl et al., 2013

Combination approaches may prove optimal for many individuals

For beginners, it's advisable to start at the lower end (2040 mcg/day) to assess tolerance and minimize side effects (Siddle, Growth Hormone & IGF Research )

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