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This work was supported by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia (Grants No

Diets high in added sugars can blunt GLP-1 release over time, disrupting gut hormone signaling and contributing to blood sugar spikes that overwhelm the bodys natural appetite regulation

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N Engl J Med (2016) 375:31122

We have searched the complete clinical trials ( to reduce IR and summarized them mainly include: (1) Diet intervention, such as Low-fat vegetarian Food, high-protein food, calorie restriction, vitamin D supplementation to reduce the IR in human obesity