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In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]
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Ipamorelin is a synthetic pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) developed in the early 1990s by Novo Nordisk
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administration, which allows once-daily administration with activity throughout the 24 h period
Synthetic biology-based approaches, such as SYNB1891, a live microbial vector delivering STING agonists, have been evaluated for intratumoral immune activation in metastatic tumors (NCT04167137)
