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Abraham Arimuko, MD

This atrophy and loss of function are often a primary cause of neuropathology, as for example is caused by substantial decreases in expression and function of glutamate transporters in Wernicke-Korsakoff encephalopathy or toxic brain damage

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Switching to semaglutide may help because the single-receptor approach sometimes produces milder GI effects, but the improvement is not guaranteed

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It also stimulates the overexpression of the transient receptor potential melastatin 2 (TRPM2) ion channels, triggering macrophage activation, leading to a systemic immune response