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When pain persists beyond three months, when ultrasound shows structural degeneration, or when conservative measures have plateaued that's when we escalate

A 2021 review examining NNMT as a drug target explicitly notes that NNMT-inhibitor drugs remain limited in clinical use and that the field is still working out selectivity and delivery

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Most experienced researchers recommend dropping back to a lower escalation dose and working up gradually, even with prior GLP-1 agonist experience

I know people whove used it to deal with funky elbow discomfort

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