Delafloxacin, a non-zwitterionic fluoroquinolone in phase III of clinical development: Evaluation of its pharmacology, pharmacokinetics, pharmacodynamics and clinical efficacy
Optional: finish with a squeeze of fresh lime juice for brightness
et al, Short-term and long-term variability of plasma homocysteine measurement
C., Nagy, P., Bianco, C
Nodules larger than 4cm are more likely to cause pressure symptoms, but most small nodules (under 1cm) remain completely asymptomatic
Clinically, observational studies have linked specific microbiome unit reduced microbial diversity, depletion of butyrate-producing taxa, and an altered estrobolome to higher breast cancer risk or more aggressive phenotypes, and small interventional trials and pilot studies have explored probiotic supplementation (commonly Lactobacillus and Bifidobacterium strains) (176), showing encouraging signals such as improvement in systemic inflammatory markers, attenuation of gastrointestinal and mucosal toxicities during chemotherapy, mitigation of antibiotic-associated diarrhoea, modest improvements in metabolic parameters and bone health, and favourable changes in gut microbial composition