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"So, when people come off a medication that they need to treat a chronic condition -- which the conditions of overweight and obesity are -- of course, rebound weight gain is possible, if not likely." In the United States, obesity affects nearly 42% of the population and is associated with over $170 billion in medical costs, according to the Centers for Disease Control and Prevention
In patients losing weight rapidly, muscle mass loss accelerates if protein intake falls below approximately 1.2 g per kilogram of body weight per day
Cell 36 , 845860 (2009)
Do appetite effects get stronger over time
Other side effects include dizziness, mild tachycardia, infections, headaches, and indigestion
Disruption of SUMOylation has been implicated in AD, HD and PD, where it contributes to protein aggregation, synaptic dysfunction, and neuronal vulnerability
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