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10 Since the patient in Case #2 was asymptomatic and the optic disc edema was an incidental finding, it is difficult to know exactly how long the optic disc edema was present prior to presentation
However, a significant decrease in insulinotropic activity was observed with GIP in diabetic patient with hyperglycemia, whereas relatively preserved activity was noted with GLP-1 in the same patients (58), suggesting divergent effects of GIP and GLP-1 on -cells ( Figure 1 Section B)
For example, GLP1RAs-induced weight loss might affect drug distribution
Bibcode:2026ER....29223689K
In trials, the drug caused thyroid C-cell tumors in rodents, although it is unknown whether Zepbound can result in the same cancer in humans
In April 2026 the agency clarified that compounders cannot sell what amounts to a copy of a commercially available drug in the same or similar strength
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