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doi:10.1016/S0098-2997(01)00013-9 57
Marjot T, Moolla A, Cobbold JF, Hodson L, Tomlinson JW
Melanotan-2: The Shotgun Approach MT-2 hits the same MC1R receptor but also activates MC3R, MC4R, and MC5R : MC1R Melanin production (tanning) MC3R Energy homeostasis, cardiovascular function MC4R Sexual arousal, appetite regulation, erectile function MC5R Exocrine gland function, sebaceous secretion This non-selective binding is why MT-2 causes the "side effects" that many users actually seek out particularly the libido and appetite suppression effects
Monitor medications : Some medicines may increase headache riskinform your doctor
So, uncertainty remains about safety in this population and caution is advised, noting that this concern really only applies to those with the most severe heart failure