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3.5 Strategic implications Taken together, the developments described abovenamely, the maturation of long-acting peptide design, the conceptual shift toward rational polypharmacology, the availability of improved mechanistic validation tools, and the evolution of clinical and regulatory expectationssuggest that the present moment represents an inflection point for underexplored peptidereceptor systems

Mounjaro is not recommended in patients with: Severe gastrointestinal disease , including severe gastroparesis, as Mounjaro further slows gastric emptying Caution is advised in patients with: History of pancreatitis careful consideration and monitoring are required Diabetic retinopathy rapid glycaemic improvement may transiently worsen retinopathy, particularly in patients on insulin No dose adjustment is required in renal impairment, though renal function should be monitored if significant gastrointestinal adverse effects or dehydration occur

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If you experience severe, persistent abdominal pain (particularly if radiating to the back), this may indicate pancreatitisa rare but serious complication